CNN explores the decade of research on Rapamycin and its potential as anti-aging drug. It has been administered to dogs with good results and to a small number of human subjects.

“It’s been remarkable,” Paola Anderson said as she watched Momo, her 13-year-old white Pomsky, run around the backyard, keeping up with dogs a third his age.
The drug is called rapamycin. After nearly a decade of research showing that it makes mice live up to 60% longer, scientists are trying it out as an anti-aging drug in dogs and humans.

Novartis gave rapamycin to 218 elderly volunteers, and it enhanced their response to the flu vaccine by 20%.
The results “raise the possibility that (rapamycin) may have beneficial effects” on the decline in immune function that occurs naturally as we get older, the study authors wrote.
They reported that the side effects of rapamycin were “relatively well-tolerated.” Severe side effects, they wrote, occurred at a “similar” rate as those experienced by the patients in the study who took a placebo, or a sugar pill.
Of the 53 patients on the lowest dose of rapamycin, 22 suffered some side effect, most commonly mouth sores.
Dr. Monica Mita, who’s done her own research with drugs like rapamycin, said she thinks the side effects can be managed.
“It’s really a matter of using the right dose and keeping an eye on the patients,” said Mita, co-director of experimental therapeutics at Cedars-Sinai hospital in Los Angeles.

More info here: http://edition.cnn.com/2016/10/06/health/rapamycin-dog-live-longer/index.html